Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf. / Agerholm, Jørgen S.; Mason, Gary; Steffen, David.

In: Journal of Veterinary Diagnostic Investigation, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Agerholm, JS, Mason, G & Steffen, D 2024, 'Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf', Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/10406387241245778

APA

Agerholm, J. S., Mason, G., & Steffen, D. (2024). Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/10406387241245778

Vancouver

Agerholm JS, Mason G, Steffen D. Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf. Journal of Veterinary Diagnostic Investigation. 2024. https://doi.org/10.1177/10406387241245778

Author

Agerholm, Jørgen S. ; Mason, Gary ; Steffen, David. / Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf. In: Journal of Veterinary Diagnostic Investigation. 2024.

Bibtex

@article{557b07e075f146a29fb5828b396a3ce6,
title = "Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf",
abstract = "Distinct solitary dermal nodules, either covered by an alopecic, or sometimes ulcerated, epidermis, were noticed on the head of a stillborn Holstein calf. The head was submitted for autopsy, and the nodules were found to consist of homogeneous, diffuse pale-yellow, soft-tissue masses with distinct margins that elevated the epidermis above the adjacent skin. Histologically, the dermal nodules were well-delineated on the deep margin approaching the cutaneous muscle and consisted of perivascular neoplastic infiltrates of round cells that in some places coalesced into sheets that extended into the dermis and subcutis. Neoplastic cells separated adnexa and collagen. Immunohistochemistry revealed intense tumor cell expression of vimentin, Iba1, E-cadherin, and CD204; expression of CD18 was faint. The masses were diagnosed as Langerhans cell histiocytosis. Congenital cutaneous Langerhans cell histiocytosis has not been reported previously in cattle, to our knowledge, and should be included in the differential diagnosis of congenital nodular skin lesions.",
keywords = "calves, CD204, E-cadherin, Iba1, immunohistochemistry, skin tumor",
author = "Agerholm, {J{\o}rgen S.} and Gary Mason and David Steffen",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s).",
year = "2024",
doi = "10.1177/10406387241245778",
language = "English",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Congenital localized cutaneous Langerhans cell histiocytosis in a Holstein calf

AU - Agerholm, Jørgen S.

AU - Mason, Gary

AU - Steffen, David

N1 - Publisher Copyright: © 2024 The Author(s).

PY - 2024

Y1 - 2024

N2 - Distinct solitary dermal nodules, either covered by an alopecic, or sometimes ulcerated, epidermis, were noticed on the head of a stillborn Holstein calf. The head was submitted for autopsy, and the nodules were found to consist of homogeneous, diffuse pale-yellow, soft-tissue masses with distinct margins that elevated the epidermis above the adjacent skin. Histologically, the dermal nodules were well-delineated on the deep margin approaching the cutaneous muscle and consisted of perivascular neoplastic infiltrates of round cells that in some places coalesced into sheets that extended into the dermis and subcutis. Neoplastic cells separated adnexa and collagen. Immunohistochemistry revealed intense tumor cell expression of vimentin, Iba1, E-cadherin, and CD204; expression of CD18 was faint. The masses were diagnosed as Langerhans cell histiocytosis. Congenital cutaneous Langerhans cell histiocytosis has not been reported previously in cattle, to our knowledge, and should be included in the differential diagnosis of congenital nodular skin lesions.

AB - Distinct solitary dermal nodules, either covered by an alopecic, or sometimes ulcerated, epidermis, were noticed on the head of a stillborn Holstein calf. The head was submitted for autopsy, and the nodules were found to consist of homogeneous, diffuse pale-yellow, soft-tissue masses with distinct margins that elevated the epidermis above the adjacent skin. Histologically, the dermal nodules were well-delineated on the deep margin approaching the cutaneous muscle and consisted of perivascular neoplastic infiltrates of round cells that in some places coalesced into sheets that extended into the dermis and subcutis. Neoplastic cells separated adnexa and collagen. Immunohistochemistry revealed intense tumor cell expression of vimentin, Iba1, E-cadherin, and CD204; expression of CD18 was faint. The masses were diagnosed as Langerhans cell histiocytosis. Congenital cutaneous Langerhans cell histiocytosis has not been reported previously in cattle, to our knowledge, and should be included in the differential diagnosis of congenital nodular skin lesions.

KW - calves

KW - CD204

KW - E-cadherin

KW - Iba1, immunohistochemistry

KW - skin tumor

U2 - 10.1177/10406387241245778

DO - 10.1177/10406387241245778

M3 - Journal article

C2 - 38616510

AN - SCOPUS:85190509539

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

ER -

ID: 390246376