c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals
Research output: Contribution to journal › Journal article › Research › peer-review
Chronic low-grade activation of the immune system (CLAIS) predicts type 2 diabetes via a decrease in insulin sensitivity. Our study investigated potential relationships between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK) pathways-two pathways proposed as the link between CLAIS and insulin resistance.
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 58 |
| Issue number | 6 |
| Pages (from-to) | 1259-65 |
| Number of pages | 7 |
| ISSN | 0012-1797 |
| DOIs | |
| Publication status | Published - 1 Jun 2009 |
- Adolescent, Adult, Biopsy, Blood Glucose, Body Mass Index, Cell Nucleus, DNA Primers, Female, Humans, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Leukocyte Count, Leukocytes, Mononuclear, Male, Middle Aged, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, Muscle, Skeletal, NF-kappa B, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, Subcutaneous Fat, Waist-Hip Ratio, Young Adult, eIF-2 Kinase
Research areas
ID: 33899737