Blood-brain barrier permeability during shortlasting intravascular hyperosmolality

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Blood-brain barrier permeability during shortlasting intravascular hyperosmolality. / Paulson, O B; Hertz, M M.

In: European Journal of Clinical Investigation, Vol. 8, No. 6, 12.1978, p. 391-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Paulson, OB & Hertz, MM 1978, 'Blood-brain barrier permeability during shortlasting intravascular hyperosmolality', European Journal of Clinical Investigation, vol. 8, no. 6, pp. 391-6. https://doi.org/10.1111/j.1365-2362.1978.tb00870.x

APA

Paulson, O. B., & Hertz, M. M. (1978). Blood-brain barrier permeability during shortlasting intravascular hyperosmolality. European Journal of Clinical Investigation, 8(6), 391-6. https://doi.org/10.1111/j.1365-2362.1978.tb00870.x

Vancouver

Paulson OB, Hertz MM. Blood-brain barrier permeability during shortlasting intravascular hyperosmolality. European Journal of Clinical Investigation. 1978 Dec;8(6):391-6. https://doi.org/10.1111/j.1365-2362.1978.tb00870.x

Author

Paulson, O B ; Hertz, M M. / Blood-brain barrier permeability during shortlasting intravascular hyperosmolality. In: European Journal of Clinical Investigation. 1978 ; Vol. 8, No. 6. pp. 391-6.

Bibtex

@article{ed3c8a626c214db498a32b1b65622d46,
title = "Blood-brain barrier permeability during shortlasting intravascular hyperosmolality",
abstract = "Blood-brain barrier permeability for 24Na+ and 36Cl- ions and for 3HOH was studied during isoosmolality and during shortlasting intravascular hyperosmolality in twenty-five patients using the double indicatir single injection method. Hyperosmolality was induced by a rapid injection into the internal carotid artery of 8 ml of one of the following hypertonic solutions: 5% saline, 25% mannitol or a contrast medium of the metrizoat group (Isopaque-amine 280). The extractions of the small sodium and chloride ions remained unchanged and essentially zero indicating that 'opening' of the blood-brain barrier did not occur. The blood-brain barrier permeability to water remained unchanged during hyperosmolality, but the extraction of 3HOH increased when mannitol and especially when Isopaque-amine 280 was used as hypertonic agent corresponding to the lower water concentration in these solutions.",
keywords = "Blood-Brain Barrier, Body Water/metabolism, Chlorine/metabolism, Contrast Media, Humans, Hypertonic Solutions, Mannitol/administration & dosage, Osmolar Concentration, Permeability, Saline Solution, Hypertonic, Sodium/metabolism",
author = "Paulson, {O B} and Hertz, {M M}",
year = "1978",
month = dec,
doi = "10.1111/j.1365-2362.1978.tb00870.x",
language = "English",
volume = "8",
pages = "391--6",
journal = "European Journal of Clinical Investigation, Supplement",
issn = "0960-135X",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Blood-brain barrier permeability during shortlasting intravascular hyperosmolality

AU - Paulson, O B

AU - Hertz, M M

PY - 1978/12

Y1 - 1978/12

N2 - Blood-brain barrier permeability for 24Na+ and 36Cl- ions and for 3HOH was studied during isoosmolality and during shortlasting intravascular hyperosmolality in twenty-five patients using the double indicatir single injection method. Hyperosmolality was induced by a rapid injection into the internal carotid artery of 8 ml of one of the following hypertonic solutions: 5% saline, 25% mannitol or a contrast medium of the metrizoat group (Isopaque-amine 280). The extractions of the small sodium and chloride ions remained unchanged and essentially zero indicating that 'opening' of the blood-brain barrier did not occur. The blood-brain barrier permeability to water remained unchanged during hyperosmolality, but the extraction of 3HOH increased when mannitol and especially when Isopaque-amine 280 was used as hypertonic agent corresponding to the lower water concentration in these solutions.

AB - Blood-brain barrier permeability for 24Na+ and 36Cl- ions and for 3HOH was studied during isoosmolality and during shortlasting intravascular hyperosmolality in twenty-five patients using the double indicatir single injection method. Hyperosmolality was induced by a rapid injection into the internal carotid artery of 8 ml of one of the following hypertonic solutions: 5% saline, 25% mannitol or a contrast medium of the metrizoat group (Isopaque-amine 280). The extractions of the small sodium and chloride ions remained unchanged and essentially zero indicating that 'opening' of the blood-brain barrier did not occur. The blood-brain barrier permeability to water remained unchanged during hyperosmolality, but the extraction of 3HOH increased when mannitol and especially when Isopaque-amine 280 was used as hypertonic agent corresponding to the lower water concentration in these solutions.

KW - Blood-Brain Barrier

KW - Body Water/metabolism

KW - Chlorine/metabolism

KW - Contrast Media

KW - Humans

KW - Hypertonic Solutions

KW - Mannitol/administration & dosage

KW - Osmolar Concentration

KW - Permeability

KW - Saline Solution, Hypertonic

KW - Sodium/metabolism

U2 - 10.1111/j.1365-2362.1978.tb00870.x

DO - 10.1111/j.1365-2362.1978.tb00870.x

M3 - Journal article

C2 - 105911

VL - 8

SP - 391

EP - 396

JO - European Journal of Clinical Investigation, Supplement

JF - European Journal of Clinical Investigation, Supplement

SN - 0960-135X

IS - 6

ER -

ID: 260211023