2-(2,3-Dihydro-1H-indol-3-yl)ethanol: synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis
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2-(2,3-Dihydro-1H-indol-3-yl)ethanol : synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis. / Frydenvang, Karla Andrea; Sommer, Michael Bech; Heckmann, Dieter; Nielsen, Ole; Bang-Andersen, Benny.
In: Chirality, Vol. 16, No. 2, 2004, p. 126-30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 2-(2,3-Dihydro-1H-indol-3-yl)ethanol
T2 - synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis
AU - Frydenvang, Karla Andrea
AU - Sommer, Michael Bech
AU - Heckmann, Dieter
AU - Nielsen, Ole
AU - Bang-Andersen, Benny
N1 - Copyright 2004 Wiley-Liss, Inc.
PY - 2004
Y1 - 2004
N2 - The first direct resolution of racemic 2-(2,3-dihydro-lH-indol-3-yl)ethanol-prepared by catalytic hydrogenation of 2-(lH-indol-3-yl)ethanol-has been accomplished by chiral simulated moving bed (SMB) chromatography. The single enantiomers were isolated as their dihydrogen phosphate salts. Single-crystal X-ray analyses were successful, revealing that the (+)-enantiomer of 2-(2,3-dihydro-lH-indol-3-yl)ethanol has the (S) configuration. Chirality 16:126-130, 2004.
AB - The first direct resolution of racemic 2-(2,3-dihydro-lH-indol-3-yl)ethanol-prepared by catalytic hydrogenation of 2-(lH-indol-3-yl)ethanol-has been accomplished by chiral simulated moving bed (SMB) chromatography. The single enantiomers were isolated as their dihydrogen phosphate salts. Single-crystal X-ray analyses were successful, revealing that the (+)-enantiomer of 2-(2,3-dihydro-lH-indol-3-yl)ethanol has the (S) configuration. Chirality 16:126-130, 2004.
KW - Chromatography, High Pressure Liquid
KW - Crystallography, X-Ray
KW - Ethanol
KW - Hydrogen
KW - Indoles
KW - Ligands
KW - Models, Molecular
KW - Molecular Conformation
KW - Molecular Structure
KW - Phosphates
KW - Receptors, Dopamine D2
KW - Receptors, Dopamine D4
KW - Stereoisomerism
U2 - 10.1002/chir.10313
DO - 10.1002/chir.10313
M3 - Journal article
C2 - 14712476
VL - 16
SP - 126
EP - 130
JO - Chirality
JF - Chirality
SN - 0899-0042
IS - 2
ER -
ID: 40371290