The time is now: Regular exercise maintains vascular health in aging women

Research output: Contribution to journalReviewResearchpeer-review

Standard

The time is now: Regular exercise maintains vascular health in aging women. / Tamariz‐Ellemann, Andrea; Wickham, Kate Aiko; Nørregaard, Line Boel; Gliemann, Lasse; Hellsten, Ylva.

In: Journal of Physiology, 2023.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Tamariz‐Ellemann, A, Wickham, KA, Nørregaard, LB, Gliemann, L & Hellsten, Y 2023, 'The time is now: Regular exercise maintains vascular health in aging women', Journal of Physiology. https://doi.org/10.1113/JP282896

APA

Tamariz‐Ellemann, A., Wickham, K. A., Nørregaard, L. B., Gliemann, L., & Hellsten, Y. (2023). The time is now: Regular exercise maintains vascular health in aging women. Journal of Physiology, [JP282896]. https://doi.org/10.1113/JP282896

Vancouver

Tamariz‐Ellemann A, Wickham KA, Nørregaard LB, Gliemann L, Hellsten Y. The time is now: Regular exercise maintains vascular health in aging women. Journal of Physiology. 2023. JP282896. https://doi.org/10.1113/JP282896

Author

Tamariz‐Ellemann, Andrea ; Wickham, Kate Aiko ; Nørregaard, Line Boel ; Gliemann, Lasse ; Hellsten, Ylva. / The time is now: Regular exercise maintains vascular health in aging women. In: Journal of Physiology. 2023.

Bibtex

@article{ba56824acdab4841801e571e8df9c9f0,
title = "The time is now: Regular exercise maintains vascular health in aging women",
abstract = "Although aging impairs cardiovascular health in both men and women, the timeline is different between the sexes. This is at least partially attributed to the loss of estrogen in women at midlife, in connection with menopause. Estrogen has protective effects on the cardiovascular system, and menopause consequently leads to a rapid and significant decline in cardiovascular health. Notably, estrogen interacts with its nuclear and membrane receptors leading to changes in proteins of importance for cardiovascular health. Skeletal muscle activity, which affects the expression of many of the same proteins as estrogen, could potentially counteract the loss of estrogen at menopause. The hypothesis that exercise can counteract the loss of estrogen has been explored in several recent studies. It has been found that regular physical activity opposes the detrimental effects not only of aging, but also the menopausal transition, on cardiovascular health. Although, vascular benefits can be gained at all ages, initiating physical activity at or soon after menopause may be more effective than at a later time point in life. Intuitively, it is easier to prevent decrements than attempting to regain lost vascular health. This idea is supported by evidence at the molecular level, suggesting that exercise-induced activation of the estrogen-related receptor-α pathway is more effective soon after menopause compared to later. Together, although a decline in cardiovascular health due to chronological aging cannot be completely prevented, a physically active lifestyle mitigates age-related cardiovascular impairments. Importantly, regular physical activity through life should always be addressed as the biological norm.",
keywords = "Faculty of Science, Aging, Exercise, Menopause, Vascular Health",
author = "Andrea Tamariz‐Ellemann and Wickham, {Kate Aiko} and N{\o}rregaard, {Line Boel} and Lasse Gliemann and Ylva Hellsten",
note = "(CURIS 2022 NEXS 269) --> Flyttet til 2023 og afventer endelig publicering. Published online: 27 October 2022.",
year = "2023",
doi = "10.1113/JP282896",
language = "English",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - The time is now: Regular exercise maintains vascular health in aging women

AU - Tamariz‐Ellemann, Andrea

AU - Wickham, Kate Aiko

AU - Nørregaard, Line Boel

AU - Gliemann, Lasse

AU - Hellsten, Ylva

N1 - (CURIS 2022 NEXS 269) --> Flyttet til 2023 og afventer endelig publicering. Published online: 27 October 2022.

PY - 2023

Y1 - 2023

N2 - Although aging impairs cardiovascular health in both men and women, the timeline is different between the sexes. This is at least partially attributed to the loss of estrogen in women at midlife, in connection with menopause. Estrogen has protective effects on the cardiovascular system, and menopause consequently leads to a rapid and significant decline in cardiovascular health. Notably, estrogen interacts with its nuclear and membrane receptors leading to changes in proteins of importance for cardiovascular health. Skeletal muscle activity, which affects the expression of many of the same proteins as estrogen, could potentially counteract the loss of estrogen at menopause. The hypothesis that exercise can counteract the loss of estrogen has been explored in several recent studies. It has been found that regular physical activity opposes the detrimental effects not only of aging, but also the menopausal transition, on cardiovascular health. Although, vascular benefits can be gained at all ages, initiating physical activity at or soon after menopause may be more effective than at a later time point in life. Intuitively, it is easier to prevent decrements than attempting to regain lost vascular health. This idea is supported by evidence at the molecular level, suggesting that exercise-induced activation of the estrogen-related receptor-α pathway is more effective soon after menopause compared to later. Together, although a decline in cardiovascular health due to chronological aging cannot be completely prevented, a physically active lifestyle mitigates age-related cardiovascular impairments. Importantly, regular physical activity through life should always be addressed as the biological norm.

AB - Although aging impairs cardiovascular health in both men and women, the timeline is different between the sexes. This is at least partially attributed to the loss of estrogen in women at midlife, in connection with menopause. Estrogen has protective effects on the cardiovascular system, and menopause consequently leads to a rapid and significant decline in cardiovascular health. Notably, estrogen interacts with its nuclear and membrane receptors leading to changes in proteins of importance for cardiovascular health. Skeletal muscle activity, which affects the expression of many of the same proteins as estrogen, could potentially counteract the loss of estrogen at menopause. The hypothesis that exercise can counteract the loss of estrogen has been explored in several recent studies. It has been found that regular physical activity opposes the detrimental effects not only of aging, but also the menopausal transition, on cardiovascular health. Although, vascular benefits can be gained at all ages, initiating physical activity at or soon after menopause may be more effective than at a later time point in life. Intuitively, it is easier to prevent decrements than attempting to regain lost vascular health. This idea is supported by evidence at the molecular level, suggesting that exercise-induced activation of the estrogen-related receptor-α pathway is more effective soon after menopause compared to later. Together, although a decline in cardiovascular health due to chronological aging cannot be completely prevented, a physically active lifestyle mitigates age-related cardiovascular impairments. Importantly, regular physical activity through life should always be addressed as the biological norm.

KW - Faculty of Science

KW - Aging

KW - Exercise

KW - Menopause

KW - Vascular Health

U2 - 10.1113/JP282896

DO - 10.1113/JP282896

M3 - Review

C2 - 36300822

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

M1 - JP282896

ER -

ID: 323839797