The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology
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The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology. / Venning, Freja Albjerg; Claesson, Mogens Helweg; Kissow, Hannelouise.
In: Journal of Cancer Science & Therapy, Vol. 5, No. 11, 2013, p. 377-383.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology
AU - Venning, Freja Albjerg
AU - Claesson, Mogens Helweg
AU - Kissow, Hannelouise
PY - 2013
Y1 - 2013
N2 - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.
AB - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.
KW - Faculty of Health and Medical Sciences
KW - Neoplasia
KW - Carcinogenic agent azoxymethane
KW - Histopathology
U2 - 10.4172/1948-5956.1000229
DO - 10.4172/1948-5956.1000229
M3 - Journal article
VL - 5
SP - 377
EP - 383
JO - Journal of Cancer Science and Therapy
JF - Journal of Cancer Science and Therapy
SN - 1948-5956
IS - 11
ER -
ID: 91450447