Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters. / Præstmark, Kezia Ann; Stallknecht, Bente Merete; Bo Jensen, Casper ; Berg Madsen, Nils; Kildegaard, Jonas.

In: Journal of Diabetes Science and Technology, Vol. 8, No. 4, 17.04.2014, p. 752-759.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Præstmark, KA, Stallknecht, BM, Bo Jensen, C, Berg Madsen, N & Kildegaard, J 2014, 'Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters', Journal of Diabetes Science and Technology, vol. 8, no. 4, pp. 752-759. https://doi.org/10.1177/1932296814531099

APA

Præstmark, K. A., Stallknecht, B. M., Bo Jensen, C., Berg Madsen, N., & Kildegaard, J. (2014). Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters. Journal of Diabetes Science and Technology, 8(4), 752-759. https://doi.org/10.1177/1932296814531099

Vancouver

Præstmark KA, Stallknecht BM, Bo Jensen C, Berg Madsen N, Kildegaard J. Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters. Journal of Diabetes Science and Technology. 2014 Apr 17;8(4):752-759. https://doi.org/10.1177/1932296814531099

Author

Præstmark, Kezia Ann ; Stallknecht, Bente Merete ; Bo Jensen, Casper ; Berg Madsen, Nils ; Kildegaard, Jonas. / Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters. In: Journal of Diabetes Science and Technology. 2014 ; Vol. 8, No. 4. pp. 752-759.

Bibtex

@article{5d77a3657e834341bc3b3ab9c8c92ef0,
title = "Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters",
abstract = "Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating skin blood perfusion response around needle insertion sites. Three common sized pen needles of 28G, 30G, and 32G as well as hooked 32G needles, were inserted into the neck skin of pigs and then removed. Laser Speckle Contrast Analysis was used to measure skin blood perfusion for 20 minutes after the insertions. Seven pigs were included in the study and a total of 118 randomized needle insertions were conducted. Histology was made of tissue samples inserted with 18G, 28G, and 32G needles, and stained to quantify red and white blood cell response. Based on area under curve, calculated for each individual blood perfusion recording and grouped according to needle type, skin blood perfusion response relates to needle diameter. The response was significantly higher after insertions with 28G and hooked 32G needles than with 30G (P < .05) and 32G (P < .01) needles. Histology results were not significant, but there was a trend of an increased response with increasing needle diameter. Skin blood perfusion response to pen needle insertions rank according to needle diameter, and the tissue response caused by hooked 32G needles corresponds to that of 28G needles. The relation between needle diameter and trauma when analyzing histology was also suggested.",
keywords = "Faculty of Health and Medical Sciences, diabetes, Injections, laser speckle contrast analysis, needle size, pen needles, tissue damage",
author = "Pr{\ae}stmark, {Kezia Ann} and Stallknecht, {Bente Merete} and {Bo Jensen}, Casper and {Berg Madsen}, Nils and Jonas Kildegaard",
year = "2014",
month = "4",
day = "17",
doi = "10.1177/1932296814531099",
language = "English",
volume = "8",
pages = "752--759",
journal = "Journal of Diabetes Science and Technology",
issn = "1932-2968",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Skin Blood Perfusion and Cellular Response to Insertion of Insulin Pen Needles With Different Diameters

AU - Præstmark, Kezia Ann

AU - Stallknecht, Bente Merete

AU - Bo Jensen, Casper

AU - Berg Madsen, Nils

AU - Kildegaard, Jonas

PY - 2014/4/17

Y1 - 2014/4/17

N2 - Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating skin blood perfusion response around needle insertion sites. Three common sized pen needles of 28G, 30G, and 32G as well as hooked 32G needles, were inserted into the neck skin of pigs and then removed. Laser Speckle Contrast Analysis was used to measure skin blood perfusion for 20 minutes after the insertions. Seven pigs were included in the study and a total of 118 randomized needle insertions were conducted. Histology was made of tissue samples inserted with 18G, 28G, and 32G needles, and stained to quantify red and white blood cell response. Based on area under curve, calculated for each individual blood perfusion recording and grouped according to needle type, skin blood perfusion response relates to needle diameter. The response was significantly higher after insertions with 28G and hooked 32G needles than with 30G (P < .05) and 32G (P < .01) needles. Histology results were not significant, but there was a trend of an increased response with increasing needle diameter. Skin blood perfusion response to pen needle insertions rank according to needle diameter, and the tissue response caused by hooked 32G needles corresponds to that of 28G needles. The relation between needle diameter and trauma when analyzing histology was also suggested.

AB - Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating skin blood perfusion response around needle insertion sites. Three common sized pen needles of 28G, 30G, and 32G as well as hooked 32G needles, were inserted into the neck skin of pigs and then removed. Laser Speckle Contrast Analysis was used to measure skin blood perfusion for 20 minutes after the insertions. Seven pigs were included in the study and a total of 118 randomized needle insertions were conducted. Histology was made of tissue samples inserted with 18G, 28G, and 32G needles, and stained to quantify red and white blood cell response. Based on area under curve, calculated for each individual blood perfusion recording and grouped according to needle type, skin blood perfusion response relates to needle diameter. The response was significantly higher after insertions with 28G and hooked 32G needles than with 30G (P < .05) and 32G (P < .01) needles. Histology results were not significant, but there was a trend of an increased response with increasing needle diameter. Skin blood perfusion response to pen needle insertions rank according to needle diameter, and the tissue response caused by hooked 32G needles corresponds to that of 28G needles. The relation between needle diameter and trauma when analyzing histology was also suggested.

KW - Faculty of Health and Medical Sciences

KW - diabetes

KW - Injections

KW - laser speckle contrast analysis

KW - needle size

KW - pen needles

KW - tissue damage

U2 - 10.1177/1932296814531099

DO - 10.1177/1932296814531099

M3 - Journal article

C2 - 24876418

VL - 8

SP - 752

EP - 759

JO - Journal of Diabetes Science and Technology

JF - Journal of Diabetes Science and Technology

SN - 1932-2968

IS - 4

ER -

ID: 126686817