Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.
Research output: Contribution to journal › Journal article › peer-review
In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.
Original language | English |
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Journal | Brain Research |
Volume | 291 |
Issue number | 2 |
Pages (from-to) | 373-7 |
Number of pages | 4 |
ISSN | 0006-8993 |
Publication status | Published - 1984 |
Externally published | Yes |
Bibliographical note
Keywords: Animals; Axons; Calcium; Dendrites; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microscopy, Electron; Rats; Rats, Inbred Strains
ID: 5259546