Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.

Research output: Contribution to journalJournal articlepeer-review

  • Flemming Fryd Johansen
  • M B Jørgensen
  • D K Ekström von Lubitz
  • N H Diemer
In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.
Original languageEnglish
JournalBrain Research
Volume291
Issue number2
Pages (from-to)373-7
Number of pages4
ISSN0006-8993
Publication statusPublished - 1984
Externally publishedYes

Bibliographical note

Keywords: Animals; Axons; Calcium; Dendrites; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microscopy, Electron; Rats; Rats, Inbred Strains

ID: 5259546