Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study

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Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study. / Drummen, Mathijs; Tischmann, Lea; Gatta-Cherifi, Blandine; Cota, Daniela; Matias, Isabelle; Raben, Anne; Adam, Tanja; Westerterp-Plantenga, Margriet.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 105, No. 7, 2020, p. e2511-e2520.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Drummen, M, Tischmann, L, Gatta-Cherifi, B, Cota, D, Matias, I, Raben, A, Adam, T & Westerterp-Plantenga, M 2020, 'Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 7, pp. e2511-e2520. https://doi.org/10.1210/clinem/dgaa193

APA

Drummen, M., Tischmann, L., Gatta-Cherifi, B., Cota, D., Matias, I., Raben, A., ... Westerterp-Plantenga, M. (2020). Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study. Journal of Clinical Endocrinology and Metabolism, 105(7), e2511-e2520. https://doi.org/10.1210/clinem/dgaa193

Vancouver

Drummen M, Tischmann L, Gatta-Cherifi B, Cota D, Matias I, Raben A et al. Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study. Journal of Clinical Endocrinology and Metabolism. 2020;105(7):e2511-e2520. https://doi.org/10.1210/clinem/dgaa193

Author

Drummen, Mathijs ; Tischmann, Lea ; Gatta-Cherifi, Blandine ; Cota, Daniela ; Matias, Isabelle ; Raben, Anne ; Adam, Tanja ; Westerterp-Plantenga, Margriet. / Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study. In: Journal of Clinical Endocrinology and Metabolism. 2020 ; Vol. 105, No. 7. pp. e2511-e2520.

Bibtex

@article{8ba18615fee743ebbbaf204797ff70a1,
title = "Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study",
abstract = "Context: Endocannabinoids are suggested to play a role in energy balance regulation.Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the post-obese phase with pre-diabetes.Design and participants: Participants (n=38) were individually fed in energy balance with a medium protein (MP: 15:55:30{\%} of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30{\%} energy from P:C:F) for 48 hours in a respiration chamber.Main outcome measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to BMI (AEA) or body-fat ({\%}) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. AUC of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body-fat{\%} (P < 0.05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs. the MP group.Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, while the endocannabinoid AEA, and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure over the day.",
keywords = "Faculty of Science, Endocannabinoids, Energy balance, Adiposisty, Protein",
author = "Mathijs Drummen and Lea Tischmann and Blandine Gatta-Cherifi and Daniela Cota and Isabelle Matias and Anne Raben and Tanja Adam and Margriet Westerterp-Plantenga",
note = "{\circledC} Endocrine Society 2020.",
year = "2020",
doi = "10.1210/clinem/dgaa193",
language = "English",
volume = "105",
pages = "e2511--e2520",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Role of endocannabinoids in energy-balance regulation in participants in the postobese state - a PREVIEW study

AU - Drummen, Mathijs

AU - Tischmann, Lea

AU - Gatta-Cherifi, Blandine

AU - Cota, Daniela

AU - Matias, Isabelle

AU - Raben, Anne

AU - Adam, Tanja

AU - Westerterp-Plantenga, Margriet

N1 - © Endocrine Society 2020.

PY - 2020

Y1 - 2020

N2 - Context: Endocannabinoids are suggested to play a role in energy balance regulation.Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the post-obese phase with pre-diabetes.Design and participants: Participants (n=38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber.Main outcome measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to BMI (AEA) or body-fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. AUC of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body-fat% (P < 0.05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs. the MP group.Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, while the endocannabinoid AEA, and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure over the day.

AB - Context: Endocannabinoids are suggested to play a role in energy balance regulation.Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the post-obese phase with pre-diabetes.Design and participants: Participants (n=38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber.Main outcome measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed.Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to BMI (AEA) or body-fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. AUC of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body-fat% (P < 0.05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs. the MP group.Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, while the endocannabinoid AEA, and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure over the day.

KW - Faculty of Science

KW - Endocannabinoids

KW - Energy balance

KW - Adiposisty

KW - Protein

U2 - 10.1210/clinem/dgaa193

DO - 10.1210/clinem/dgaa193

M3 - Journal article

C2 - 32333763

VL - 105

SP - e2511-e2520

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 240979041