Polymer‐supported synthesis of deoxyoligonucleotides using in‐situ prepared deoxynucleoside 2‐cyanoethyl phosphoramidites
Research output: Contribution to journal › Journal article › Research › peer-review
The easily accessible reagent 2‐cyanoethyl‐bis (diisopropylamino) phosphoramidite is shown to be suitable for the in‐situ, 1H‐tetrazole catalysed, preparation of d‐nucleoside‐3′‐phosphoramidites. The latter compounds could be applied successfully as building blocks in a solid‐phase DNA synthesis using an automated DNA synthesizer.
| Original language | English |
|---|---|
| Journal | Recueil des Travaux Chimiques des Pays‐Bas |
| Volume | 105 |
| Issue number | 1 |
| Pages (from-to) | 33-34 |
| Number of pages | 2 |
| ISSN | 0165-0513 |
| DOIs | |
| Publication status | Published - 1 Jan 1986 |
ID: 209550819