Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host

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Standard

Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host. / Nielsen, Line; Søgaard, Mette; Jensen, Trine Hammer; Andersen, Mads Klindt; Aasted, Bent; Blixenkrone-Møller, Merete.

In: Journal of General Virology, Vol. 90, 2009, p. 2157-2165.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, L, Søgaard, M, Jensen, TH, Andersen, MK, Aasted, B & Blixenkrone-Møller, M 2009, 'Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host', Journal of General Virology, vol. 90, pp. 2157-2165. https://doi.org/10.1099/vir.0.010744-0

APA

Nielsen, L., Søgaard, M., Jensen, T. H., Andersen, M. K., Aasted, B., & Blixenkrone-Møller, M. (2009). Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host. Journal of General Virology, 90, 2157-2165. https://doi.org/10.1099/vir.0.010744-0

Vancouver

Nielsen L, Søgaard M, Jensen TH, Andersen MK, Aasted B, Blixenkrone-Møller M. Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host. Journal of General Virology. 2009;90:2157-2165. https://doi.org/10.1099/vir.0.010744-0

Author

Nielsen, Line ; Søgaard, Mette ; Jensen, Trine Hammer ; Andersen, Mads Klindt ; Aasted, Bent ; Blixenkrone-Møller, Merete. / Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host. In: Journal of General Virology. 2009 ; Vol. 90. pp. 2157-2165.

Bibtex

@article{478ff6c07c3d11de8bc9000ea68e967b,
title = "Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host",
abstract = "The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.",
keywords = "Former Faculty of Life Sciences",
author = "Line Nielsen and Mette S{\o}gaard and Jensen, {Trine Hammer} and Andersen, {Mads Klindt} and Bent Aasted and Merete Blixenkrone-M{\o}ller",
year = "2009",
doi = "10.1099/vir.0.010744-0",
language = "English",
volume = "90",
pages = "2157--2165",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",

}

RIS

TY - JOUR

T1 - Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host

AU - Nielsen, Line

AU - Søgaard, Mette

AU - Jensen, Trine Hammer

AU - Andersen, Mads Klindt

AU - Aasted, Bent

AU - Blixenkrone-Møller, Merete

PY - 2009

Y1 - 2009

N2 - The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.

AB - The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.

KW - Former Faculty of Life Sciences

U2 - 10.1099/vir.0.010744-0

DO - 10.1099/vir.0.010744-0

M3 - Journal article

C2 - 19494053

VL - 90

SP - 2157

EP - 2165

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

ER -

ID: 13413338