Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation

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Aim: To investigate comparative in vitro and in vivo performance of lipid vesicular and particulate systems in escalating oral bioavailability for superior hepatoprotection. Materials and methods: Systems were fabricated using easy to scale up process and novel excipients to deliver Silibinin. In vitro characterization followed by pharmacokinetic and pharmacodynamic evaluation in rats was conducted to establish a correlation. Results: Nanoformulations resulted in 20 fold increase in solubilisation and significant increase in permeation. 2.5 fold increase in bioavailability was evident in vivo. Vesicles demonstrated greatest hepatoprotective potential in efficacy study. Conclusion: The findings establish a link between in vitro and in vivo performance to rank order lipid nanoartchitects. Concurrently, a significant potential in therapeutic intervention of hepatotoxicity is envisaged as elucidated.

Original languageEnglish
Article number119176
JournalInternational Journal of Pharmaceutics
Volume579
ISSN0378-5173
DOIs
Publication statusPublished - 15 Apr 2020

    Research areas

  • GeluPearl, Hepatoprotection, LeciPlex, Lipid nanosystems, Liver, Oral bioavailability, Silibinin

ID: 238013530