Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lipid nanoconstructs for superior hepatoprotection : In vitro assessments as predictive tool for in vivo translation. / Dhawan, V.; Sutariya, B.; Lokras, A.; Thamm, J.; Saraf, M.; Warawdekar, U.; Fahr, A.; Nagarsenker, M.

In: International Journal of Pharmaceutics, Vol. 579, 119176, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dhawan, V, Sutariya, B, Lokras, A, Thamm, J, Saraf, M, Warawdekar, U, Fahr, A & Nagarsenker, M 2020, 'Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation', International Journal of Pharmaceutics, vol. 579, 119176. https://doi.org/10.1016/j.ijpharm.2020.119176

APA

Dhawan, V., Sutariya, B., Lokras, A., Thamm, J., Saraf, M., Warawdekar, U., Fahr, A., & Nagarsenker, M. (2020). Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. International Journal of Pharmaceutics, 579, [119176]. https://doi.org/10.1016/j.ijpharm.2020.119176

Vancouver

Dhawan V, Sutariya B, Lokras A, Thamm J, Saraf M, Warawdekar U et al. Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. International Journal of Pharmaceutics. 2020;579. 119176. https://doi.org/10.1016/j.ijpharm.2020.119176

Author

Dhawan, V. ; Sutariya, B. ; Lokras, A. ; Thamm, J. ; Saraf, M. ; Warawdekar, U. ; Fahr, A. ; Nagarsenker, M. / Lipid nanoconstructs for superior hepatoprotection : In vitro assessments as predictive tool for in vivo translation. In: International Journal of Pharmaceutics. 2020 ; Vol. 579.

Bibtex

@article{ebbc1f4da4104405af22e66b0a6e53b8,
title = "Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation",
abstract = "Aim: To investigate comparative in vitro and in vivo performance of lipid vesicular and particulate systems in escalating oral bioavailability for superior hepatoprotection. Materials and methods: Systems were fabricated using easy to scale up process and novel excipients to deliver Silibinin. In vitro characterization followed by pharmacokinetic and pharmacodynamic evaluation in rats was conducted to establish a correlation. Results: Nanoformulations resulted in 20 fold increase in solubilisation and significant increase in permeation. 2.5 fold increase in bioavailability was evident in vivo. Vesicles demonstrated greatest hepatoprotective potential in efficacy study. Conclusion: The findings establish a link between in vitro and in vivo performance to rank order lipid nanoartchitects. Concurrently, a significant potential in therapeutic intervention of hepatotoxicity is envisaged as elucidated.",
keywords = "GeluPearl, Hepatoprotection, LeciPlex, Lipid nanosystems, Liver, Oral bioavailability, Silibinin",
author = "V. Dhawan and B. Sutariya and A. Lokras and J. Thamm and M. Saraf and U. Warawdekar and A. Fahr and M. Nagarsenker",
year = "2020",
doi = "10.1016/j.ijpharm.2020.119176",
language = "English",
volume = "579",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Lipid nanoconstructs for superior hepatoprotection

T2 - In vitro assessments as predictive tool for in vivo translation

AU - Dhawan, V.

AU - Sutariya, B.

AU - Lokras, A.

AU - Thamm, J.

AU - Saraf, M.

AU - Warawdekar, U.

AU - Fahr, A.

AU - Nagarsenker, M.

PY - 2020

Y1 - 2020

N2 - Aim: To investigate comparative in vitro and in vivo performance of lipid vesicular and particulate systems in escalating oral bioavailability for superior hepatoprotection. Materials and methods: Systems were fabricated using easy to scale up process and novel excipients to deliver Silibinin. In vitro characterization followed by pharmacokinetic and pharmacodynamic evaluation in rats was conducted to establish a correlation. Results: Nanoformulations resulted in 20 fold increase in solubilisation and significant increase in permeation. 2.5 fold increase in bioavailability was evident in vivo. Vesicles demonstrated greatest hepatoprotective potential in efficacy study. Conclusion: The findings establish a link between in vitro and in vivo performance to rank order lipid nanoartchitects. Concurrently, a significant potential in therapeutic intervention of hepatotoxicity is envisaged as elucidated.

AB - Aim: To investigate comparative in vitro and in vivo performance of lipid vesicular and particulate systems in escalating oral bioavailability for superior hepatoprotection. Materials and methods: Systems were fabricated using easy to scale up process and novel excipients to deliver Silibinin. In vitro characterization followed by pharmacokinetic and pharmacodynamic evaluation in rats was conducted to establish a correlation. Results: Nanoformulations resulted in 20 fold increase in solubilisation and significant increase in permeation. 2.5 fold increase in bioavailability was evident in vivo. Vesicles demonstrated greatest hepatoprotective potential in efficacy study. Conclusion: The findings establish a link between in vitro and in vivo performance to rank order lipid nanoartchitects. Concurrently, a significant potential in therapeutic intervention of hepatotoxicity is envisaged as elucidated.

KW - GeluPearl

KW - Hepatoprotection

KW - LeciPlex

KW - Lipid nanosystems

KW - Liver

KW - Oral bioavailability

KW - Silibinin

U2 - 10.1016/j.ijpharm.2020.119176

DO - 10.1016/j.ijpharm.2020.119176

M3 - Journal article

C2 - 32119898

AN - SCOPUS:85080985550

VL - 579

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

M1 - 119176

ER -

ID: 238013530