Influence of sex differences on the progression of cancer-induced bone pain

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Influence of sex differences on the progression of cancer-induced bone pain. / Falk, Sarah; Uldall, Maria; Appel, Camilla; Ding, Ming; Heegaard, Anne-Marie.

In: Anticancer Research, Vol. 33, No. 5, 2013, p. 1963-1969.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Falk, S, Uldall, M, Appel, C, Ding, M & Heegaard, A-M 2013, 'Influence of sex differences on the progression of cancer-induced bone pain', Anticancer Research, vol. 33, no. 5, pp. 1963-1969.

APA

Falk, S., Uldall, M., Appel, C., Ding, M., & Heegaard, A-M. (2013). Influence of sex differences on the progression of cancer-induced bone pain. Anticancer Research, 33(5), 1963-1969.

Vancouver

Falk S, Uldall M, Appel C, Ding M, Heegaard A-M. Influence of sex differences on the progression of cancer-induced bone pain. Anticancer Research. 2013;33(5):1963-1969.

Author

Falk, Sarah ; Uldall, Maria ; Appel, Camilla ; Ding, Ming ; Heegaard, Anne-Marie. / Influence of sex differences on the progression of cancer-induced bone pain. In: Anticancer Research. 2013 ; Vol. 33, No. 5. pp. 1963-1969.

Bibtex

@article{e718746200e945deae325fed749751e7,
title = "Influence of sex differences on the progression of cancer-induced bone pain",
abstract = "Background: Pain caused by bone metastases has a severe impact on the quality of life for many patients with cancer. Good translational in vivo models are required to understand the molecular mechanism and develop better treatment. In the current study we evaluated the influence of sex differences on the progression of cancer-induced bone pain. Materials and Methods: 4T1-luc2 mammary cancer cells were introduced into the femoral cavity of female and male BALB/cJ mice. Bioluminescence tumor signal, pain-related behavior and bone degradation were monitored for 14 days. Results: Female mice demonstrated a significantly greater bioluminescence signal on day 2 compared to male mice and, in addition, a significant earlier onset of pain-related behavior was observed in the females. No sex difference was observed for bone degradation. Finally, a strong correlation between pain-related behavior and bone degradation was observed for both sexes. Conclusion: Although differences were observed between the sexes, these were minor and did not affect the overall progression of the pain state.",
keywords = "Faculty of Health and Medical Sciences, Pain",
author = "Sarah Falk and Maria Uldall and Camilla Appel and Ming Ding and Anne-Marie Heegaard",
note = "DOI mangler.",
year = "2013",
language = "English",
volume = "33",
pages = "1963--1969",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Influence of sex differences on the progression of cancer-induced bone pain

AU - Falk, Sarah

AU - Uldall, Maria

AU - Appel, Camilla

AU - Ding, Ming

AU - Heegaard, Anne-Marie

N1 - DOI mangler.

PY - 2013

Y1 - 2013

N2 - Background: Pain caused by bone metastases has a severe impact on the quality of life for many patients with cancer. Good translational in vivo models are required to understand the molecular mechanism and develop better treatment. In the current study we evaluated the influence of sex differences on the progression of cancer-induced bone pain. Materials and Methods: 4T1-luc2 mammary cancer cells were introduced into the femoral cavity of female and male BALB/cJ mice. Bioluminescence tumor signal, pain-related behavior and bone degradation were monitored for 14 days. Results: Female mice demonstrated a significantly greater bioluminescence signal on day 2 compared to male mice and, in addition, a significant earlier onset of pain-related behavior was observed in the females. No sex difference was observed for bone degradation. Finally, a strong correlation between pain-related behavior and bone degradation was observed for both sexes. Conclusion: Although differences were observed between the sexes, these were minor and did not affect the overall progression of the pain state.

AB - Background: Pain caused by bone metastases has a severe impact on the quality of life for many patients with cancer. Good translational in vivo models are required to understand the molecular mechanism and develop better treatment. In the current study we evaluated the influence of sex differences on the progression of cancer-induced bone pain. Materials and Methods: 4T1-luc2 mammary cancer cells were introduced into the femoral cavity of female and male BALB/cJ mice. Bioluminescence tumor signal, pain-related behavior and bone degradation were monitored for 14 days. Results: Female mice demonstrated a significantly greater bioluminescence signal on day 2 compared to male mice and, in addition, a significant earlier onset of pain-related behavior was observed in the females. No sex difference was observed for bone degradation. Finally, a strong correlation between pain-related behavior and bone degradation was observed for both sexes. Conclusion: Although differences were observed between the sexes, these were minor and did not affect the overall progression of the pain state.

KW - Faculty of Health and Medical Sciences

KW - Pain

M3 - Journal article

VL - 33

SP - 1963

EP - 1969

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5

ER -

ID: 45846987