IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes

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IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number5
Pages (from-to)614-620
Number of pages7
Publication statusPublished - 2013

ID: 45791918