TY - JOUR

T1 - High fat diets for weight loss among subjects with elevated fasting glucose levels: The PREDIMED study

AU - Hjorth, Mads Fiil

AU - Corella, Dolores

AU - Astrup, Arne

AU - Ruiz-Canela, Miguel

AU - Salas-Salvado, Jordi

AU - Fito, Montserrat

AU - Martínez-González, Julio

AU - Romaguera, Dora

AU - Lapetra, José

AU - Estruch, Ramón

AU - Serra-Majem, Luis

AU - Pinto, Xavier

AU - Alonso-Gómez, Ángel

AU - Martínez, J Alfredo

AU - Martínez-González, Miguel A

N1 - CURIS 2020 NEXS 091

PY - 2020

Y1 - 2020

N2 - Aim: We studied fasting plasma glucose (FPG) as a determinant of weight change on high-fat diets in the PREDIMED trial. Methods: A total of 3,622 participants were randomized to receive one of two Mediterranean diets (n = 2,616) or a control diet (n = 1,006) for 5 years and had complete data for baseline FPG and body-weight development. Weight change by pre-treatment FPG categories (<100 mg/dL; 100–114.9 mg/dL; 115–125.9 mg/dL; ≥126 mg/dL) were examined. Results: The two Mediterranean diets contained 41.5 E% fat, 16.5 E% protein, and 40 E% carbohydrate whereas the control diet contained 37.8 E% fat, 16.8 E% protein and 43.2 E% carbohydrate. In the Mediterranean diet groups, participants with FPG≥115 lost 1.04 kg (95% CI 0.68; 1.41, n = 1115) whereas participants with FPG<115 mg/dL lost 0.30 kg (95% CI -0.01; 0.60, n = 1501) resulting in a between-group difference of 0.75 kg (95% CI 0.20; 1.30, P = 0.007). Similar, although none-significant, between-group difference was observed in the control group [0.70 kg (95% CI -0.25; 1.65, P = 0.15)]. Conclusions: Participants with elevated pre-treatment FPG lost more weight than participants with lower FPG on these three moderate to high fat diets. Although the effect size is small, results are important as these individuals represent those in most need of weight loss.

AB - Aim: We studied fasting plasma glucose (FPG) as a determinant of weight change on high-fat diets in the PREDIMED trial. Methods: A total of 3,622 participants were randomized to receive one of two Mediterranean diets (n = 2,616) or a control diet (n = 1,006) for 5 years and had complete data for baseline FPG and body-weight development. Weight change by pre-treatment FPG categories (<100 mg/dL; 100–114.9 mg/dL; 115–125.9 mg/dL; ≥126 mg/dL) were examined. Results: The two Mediterranean diets contained 41.5 E% fat, 16.5 E% protein, and 40 E% carbohydrate whereas the control diet contained 37.8 E% fat, 16.8 E% protein and 43.2 E% carbohydrate. In the Mediterranean diet groups, participants with FPG≥115 lost 1.04 kg (95% CI 0.68; 1.41, n = 1115) whereas participants with FPG<115 mg/dL lost 0.30 kg (95% CI -0.01; 0.60, n = 1501) resulting in a between-group difference of 0.75 kg (95% CI 0.20; 1.30, P = 0.007). Similar, although none-significant, between-group difference was observed in the control group [0.70 kg (95% CI -0.25; 1.65, P = 0.15)]. Conclusions: Participants with elevated pre-treatment FPG lost more weight than participants with lower FPG on these three moderate to high fat diets. Although the effect size is small, results are important as these individuals represent those in most need of weight loss.

KW - Glucose

KW - High-fat diet

KW - Mediterranean diet

KW - Type 2 diabetes

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=85081382665&partnerID=8YFLogxK

U2 - 10.1016/j.obmed.2020.100210

DO - 10.1016/j.obmed.2020.100210

M3 - Journal article

AN - SCOPUS:85081382665

VL - 18

JO - Obesity Medicine

JF - Obesity Medicine

SN - 2451-8476

M1 - 100210

ER -