Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Exploration of PNA-peptide conjugates as potential antisense antibiotics necessitates a fast and efficient synthesis protocols for amounts that facilitate determination of structure-activity relationships and in vivo studies in animal infection models. Fmoc/Boc-protected PNA monomers are here used for assembly of oligomers by optimized protocols involving either a manual synthesis method at room temperature or automated microwave-assisted coupling of monomers on a peptide synthesizer.
Original language | English |
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Title of host publication | Peptide Nucleic Acids : Methods and Protocols |
Editors | Peter E. Nielsen |
Number of pages | 16 |
Publisher | Humana Press |
Publication date | 2020 |
Pages | 1-16 |
ISBN (Print) | 978-1-0716-0242-3 |
ISBN (Electronic) | 978-1-0716-0243-0 |
DOIs | |
Publication status | Published - 2020 |
Series | Methods in molecular biology (Clifton, N.J.) |
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Volume | 2105 |
ISSN | 1064-3745 |
ID: 269723379