Biotechnological Trends in Spider and Scorpion Antivenom Development

Research output: Contribution to journalJournal articlepeer-review

Standard

Biotechnological Trends in Spider and Scorpion Antivenom Development. / Laustsen, Andreas Hougaard; Solà, Mireia; Jappe, Emma Christine; Oscoz Cob, Saioa; Lauridsen, Line; Engmark, Mikael.

In: Toxins, Vol. 8, No. 8, 226, 2016, p. 1-33.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Laustsen, AH, Solà, M, Jappe, EC, Oscoz Cob, S, Lauridsen, L & Engmark, M 2016, 'Biotechnological Trends in Spider and Scorpion Antivenom Development', Toxins, vol. 8, no. 8, 226, pp. 1-33. https://doi.org/10.3390/toxins8080226

APA

Laustsen, A. H., Solà, M., Jappe, E. C., Oscoz Cob, S., Lauridsen, L., & Engmark, M. (2016). Biotechnological Trends in Spider and Scorpion Antivenom Development. Toxins, 8(8), 1-33. [226]. https://doi.org/10.3390/toxins8080226

Vancouver

Laustsen AH, Solà M, Jappe EC, Oscoz Cob S, Lauridsen L, Engmark M. Biotechnological Trends in Spider and Scorpion Antivenom Development. Toxins. 2016;8(8):1-33. 226. https://doi.org/10.3390/toxins8080226

Author

Laustsen, Andreas Hougaard ; Solà, Mireia ; Jappe, Emma Christine ; Oscoz Cob, Saioa ; Lauridsen, Line ; Engmark, Mikael. / Biotechnological Trends in Spider and Scorpion Antivenom Development. In: Toxins. 2016 ; Vol. 8, No. 8. pp. 1-33.

Bibtex

@article{9c0a5a9870794574965b39deafe8a774,
title = "Biotechnological Trends in Spider and Scorpion Antivenom Development",
abstract = "Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology.",
keywords = "Faculty of Health and Medical Sciences, Antivenom, Spider Venoms, Scorpion Venoms, Antibodies, Venomics, Antivenom Design, Venom Neutralization, Antitoxins",
author = "Laustsen, {Andreas Hougaard} and Mireia Sol{\`a} and Jappe, {Emma Christine} and {Oscoz Cob}, Saioa and Line Lauridsen and Mikael Engmark",
year = "2016",
doi = "10.3390/toxins8080226",
language = "English",
volume = "8",
pages = "1--33",
journal = "Toxins",
issn = "2072-6651",
publisher = "M D P I AG",
number = "8",

}

RIS

TY - JOUR

T1 - Biotechnological Trends in Spider and Scorpion Antivenom Development

AU - Laustsen, Andreas Hougaard

AU - Solà, Mireia

AU - Jappe, Emma Christine

AU - Oscoz Cob, Saioa

AU - Lauridsen, Line

AU - Engmark, Mikael

PY - 2016

Y1 - 2016

N2 - Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology.

AB - Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology.

KW - Faculty of Health and Medical Sciences

KW - Antivenom

KW - Spider Venoms

KW - Scorpion Venoms

KW - Antibodies

KW - Venomics

KW - Antivenom Design

KW - Venom Neutralization

KW - Antitoxins

U2 - 10.3390/toxins8080226

DO - 10.3390/toxins8080226

M3 - Journal article

C2 - 27455327

VL - 8

SP - 1

EP - 33

JO - Toxins

JF - Toxins

SN - 2072-6651

IS - 8

M1 - 226

ER -

ID: 164111267