Adult Stromal (Skeletal, Mesenchymal) Stem Cells: Advances Towards Clinical Applications
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Mesenchymal Stem Cells (MSC) are non-hematopoietic adult stromal cells that reside in a perivascular niche in close association with pericytes and endothelial cells and possess self-renewal and multi-lineage differentiation capacity. The origin, unique properties, and therapeutic benefits of MSC are under intensive investigation worldwide. Several challenges with regard to the proper source of clinical-grade MSC and the efficacy of MSC-based treatment strategies need to be addressed before MSC can be routinely used in the clinic. Here, we discuss three areas that can potentially facilitate the translation of MSC into clinic: Generation of MSC-like cells from human pluripotent stem cells, strategies to enhance homing of MSC to injured tissues, and targeting of MSC in vivo.
|Title of host publication||Adult Stem Cells : Stem Cell Biology and Regenerative Medicine|
|Number of pages||15|
|Place of Publication||New York|
|Publication status||Published - 2014|
- Faculty of Health and Medical Sciences