Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives

Research output: Contribution to journalJournal articleResearchpeer-review

BackgroundPatients with bipolar disorder (BD) experience persistent impairments in both affective and non-affective cognitive function, which is associated with a worse course of illness and poor functional outcomes. Nevertheless, the temporal progression of cognitive dysfunction in BD remains unclear and the identification of objective endophenotypes can inform the aetiology of BD.MethodsThe present study is a cross-sectional investigation of cognitive baseline data from the longitudinal Bipolar Illness Onset-study. One hundred seventy-two remitted patients newly diagnosed with BD, 52 of their unaffected relatives (UR), and 110 healthy controls (HC) were compared on a large battery of behavioural cognitive tasks tapping into non-affective (i.e. neurocognitive) and affective (i.e. emotion processing and regulation) cognition.ResultsRelative to HCs, patients with BD exhibited global neurocognitive deficits (ps < 0.001), as well as aberrant emotion processing and regulation (ps â

Original languageEnglish
JournalPsychological Medicine
Pages (from-to)1-12
Publication statusAccepted/In press - Aug 2020

    Research areas

  • Affective cognition, bipolar disorder, emotion, endophenotypes, neurocognition regulation

ID: 240315393