Monomethyl branched-chain fatty acids: Health effects and biological mechanisms

Research output: Contribution to journalReviewpeer-review


Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of their effects on human health. Recently, they have been gaining interest, especially in relation to various human diseases. This review describes the occurrence of BCFA, their dietary sources, their potential health effects, and the current state of knowledge concerning their mechanism(s) of action. Many studies have been conducted so far in cellular and animal models, which reveal potent anti-cancer, lipid lowering, anti-inflammatory and neuroprotective actions. Research in humans is scarce. Therefore, further studies on animals and humans should be performed to confirm and expand these findings, and improve our understanding of the potential relevance of BCFA to human health and disease.

Original languageEnglish
Article number101226
JournalProgress in Lipid Research
Number of pages11
Publication statusPublished - 2023

Bibliographical note

Copyright © 2023. Published by Elsevier Ltd.

    Research areas

  • Faculty of Science - Branched-chain fatty acids, Nutrition, Anti-cancer properties, Lipid metabolism, Inflammation

ID: 345057794