Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza
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Background: Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared to CAP caused by bacteria or influenza virus in hospitalized patients.
Methods: A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin.
Results: Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared to bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared to the other etiologies (p<0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared to those infected with bacteria.
Conclusion: Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared to those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.
Original language | English |
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Journal | APMIS - Journal of Pathology, Microbiology and Immunology |
Volume | 130 |
Issue number | 9 |
Pages (from-to) | 590-596 |
Number of pages | 7 |
ISSN | 0903-4641 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
This article is protected by copyright. All rights reserved.
- Faculty of Science - COVID-19, Community-acquired pneumonia, Iron metabolism, Hepcidin, Ferritin, Erythroferrone, Biomarkers
Research areas
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349447/pdf/APM-130-590.pdf
Final published version
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